Diabetes >> Actos
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Actos
Active Ingredients:
- Pioglitazone
How does Actos work?
Actos is an antidiabetic drug, a selective agonist of PPAR-gamma that improves control of blood sugar. It decreases insulin resistance in peripheral tissues and the liver, causes a decrease in the concentration of glucose, insulin and glycosylated hemoglobin in the plasma.
When Actos is prescribed?
Non-insulin-dependent diabetes mellitus (II type) - as monotherapy or in combination with derivatives of sulfonylurea, metformin, or insulin in the absence of the effect of diet therapy, exercise, and monotherapy with one of the above mentioned drugs.
Before taking Actos
You should not take pioglitazone if any of these conditions apply to you:
- Hypersensitivity to pioglitazone or any other component of the drug
- Insulin-dependent diabetes mellitus (I type)
- Diabetic ketoacidosis
- Acute liver diseases
- If the level of alanine aminotransferase (ALT) is 2.5 times or more higher than normal
- Pregnancy and breastfeeding
Actos should be used with caution in the following conditions:
- Edema
- Moderate increase in liver enzymes level
- Patients below 18 years of age
Application during pregnancy and breastfeeding:
Actos is contraindicated in pregnancy. No adequate studies of Actos safety during pregnancy were conducted. Since the currently available information shows that elevated levels of blood glucose during pregnancy are linked to increased incidence of congenital abnormalities, as well as increased incidence of pathology in the neonatal period and to an increase in mortality, it is recommended to use insulin while pregnant.
It is not known whether pioglitazone is passed into the breast milk. If it is necessary to use Actos during lactation period, the breastfeeding should be stopped.
How Actos is taken?
You should take pioglitazone exactly as indicated by your physician. Do not exceed recommended dosages. Follow the directions of your prescription.
What should I do if I miss a dose?
The missed dose should be taken as soon as you remember. If it is almost time for your next dose, do not take the double dose and go on taking the drug as scheduled.
What should I do if I overdose?
Only one case of Actos overdose (120 mg/day) has been registered. However, no specific clinical symptoms were reported.
Treatment: symptomatic therapy depending on the clinical manifestations.
Which Actos side effects are possible while the treatment?
As with any drug, there are some side effects while may occur while taking pioglitazone. However, not everyone who takes Actos will experience side effects. In fact, most patients taking Actos tolerate it well. During clinical trials there were reported the following pioglitazone side effects:
- Hypoglycemia
- Edema
- Anemia, decreased hemoglobin and hematocrit
- Increased level of alanine aminotransferase/ALT, creatine phosphokinase in blood plasma
This is not a complete list of pioglitazone side effects. When side effects do occur make sure to inform your health care provider.
Which other medicines can interact with Actos?
- derivatives of sulfonylurea, metformin, insulin
- oral contraceptives
- anti-fungal agents
Make sure to inform your health care provide about prescription and over-the-counter medication, herbal supplements, and other medical preparations you are currently taking. Do not begin a new medication without letting your doctor know.
How Actos should be stored?
Store in a dry place protected from direct light at room temperature (15-30 C).
Additional information
You should not share this medicine with others. Do not take pioglitazone on your own initiative without your doctors approval. Keep the drug as well as any other disposable material out of the reach of children.
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